Petit poids de naissance et IRT, un risque augmenté de 70%

Low Birth Weight Increases Risk for End-Stage Renal Disease.
Vikse BE, Irgens LM, Leivestad T, Hallan S, Iversen BM.
J Am Soc Nephrol Publié Online le 5 décembre 2007

Case-control studies have shown an association between low birth weight and risk for renal failure. The Medical Birth Registry of Norway, which comprises data on all births in Norway since 1967, and the Norwegian Renal Registry, which comprises data on all patients who have developed ESRD in Norway since 1980, were used to examine whether birth-related variables were associated with risk for ESRD. Of the 2,183,317 children born between 1967 and 2004, 526 were found in the ESRD registry. Compared with birth weight in the 10th to 90th percentiles, births <10th percentile had a relative risk (RR) for ESRD of 1.7 (95% confidence interval 1.4 to 2.2; P < 0.001). Births with a weight for gestational age <10th percentile had an RR of 1.5 (95% confidence interval 1.2 to 1.9; P = 0.002). These associations were virtually identical after adjustment for birth-related confounders such as congenital malformations, multiple delivery, maternal age at birth, and maternal preeclampsia. Low birth weight was more strongly associated with development of ESRD during the first 14 years of life than after age 15. Low birth weight and low birth weight for gestational age were similarly associated with multiple causes of ESRD. In conclusion, in this cohort study with a maximum follow-up of 38 years, low birth weight and intrauterine growth restriction were associated with increased risk for ESRD.
Une étude très simple (à condition d'avoir des registres) et très démonstrative ! En croisant le registre nationale des naissances en Norvège entre 1967 et 2004 (2 183 317 naissances) avec le registre des insuffisants rénaux au stade terminal entre 1980 et 2005 (526 cas), et en analysant les facteurs de risque de l'IRT les auteurs de ce papier démontrent que un poids de naissance inférieur au 10ème percentile augmente le risque d'IRT de 70% jusqu'à l'âge de 38 ans (l'analyse de va pas au-dela de cet âge).
R Salomon